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Illustration to develop pH/ion responsive RADA16-I hydrogels loaded with an anti-cancer drug – EM for cancer treatment. The RADA16-I-EM suspension was injected into a cancer bearing mouse model through intra-tumoral injection, while the suspension immediately formed hydrogels in situ under the stimulation of the microenvironment in the cancer. Sustained release of EM from the hydrogels inside or beside the cancer exerts inhibitory effects on the cancer cells.
