Figure 5.

Gene expression in the aortic valves of the IE mouse model 24 h post infection with three clinical isolates of S. aureus (isolate 17 – n = 3, 30 – n = 4 and 33 –n = 3). A panel of genes associated with inflammation and autoimmune response (a) as well as extracellular matrix and adhesion molecules (b) are altered in non-infected control mice (sham– n = 4) and mice after infection with S. aureus clinical isolates 17, 30 and 33 (FC ≥|2|, one-sided Fisher-Exact test). Ingenuity pathway z score analysis of cellular and molecular biological functions (c) predicted increased activity of leukocyte migration in mice after infection with clinical isolate 17 and 30. Angiogenesis was predicted to be more pronounced in mice after infection with clinical isolate 33. -Log₁₀(p-value) was given for the top three biological functions (d). Remodeling processes were more pronounced in mice after infection with isolate 33 compared to the other two