C2 is prognostic for OS independent of AR-V status. (A) Swimmer plot ordered by OS for C2 (orange, top) and C1 (cyan, bottom). Gene expression for AR-V and AR pathway genes is indicated. X indicates the patient death. (B) Kaplan-Meier plot of OS by C2 versus C1. (C) Kaplan-Meier plot of OS by AR-V status. AR, androgen receptor; AR-V, androgen receptor splice variant; C1, cluster 1; C2, cluster 2; CRPC, castration-resistant prostate cancer; CSPC, castration-sensitive prostate cancer; HR, hazard ratio; NEPC, neuroendocrine prostate cancer; OS, overall survival.