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RAS isoform mutations. (A) Oncoprint of mutations observed in infants < 1 year old (n = 25) showed an enrichment for RAS mutations. (B) Distribution of RAS isoform mutations by age with a distinct peak of HRAS mutant cases discovered in the infant population. (C) HRAS mutations were frequently found to have a higher VAF indicating that the mutation occurred before a loss-of-heterozygosity event on chromosome 11p. VAF, variant allele frequency.
