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. 2021 Jul 3;8(17):2101210. doi: 10.1002/advs.202101210

Figure 4.

Figure 4

Release and therapeutic behaviors of macromolecular‐drug‐loaded ice microneedles. a) Optical and fluorescence images of FITC‐BSA‐loaded ice microneedles. b,c) Release profiles in PBS buffer solution of both FITC‐BSA‐loaded ice microneedles and FITC‐BSA‐loaded unfrozen microneedles (n = 6 for each group). d–f) RBC (d), HCT (e), and HGB (f) of normal mice, untreated anemia mice, and treated anemia mice after receiving erythropoietin‐loaded ice microneedles for 12 and 24 h (n = 3 for each group; Student's t‐test was conducted for comparison; * p < 0.05, ** p < 0.01, *** p < 0.001, NS: nonsignificant). Both scale bars: 500 µm.