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. 2021 Jul 8;8(17):2100629. doi: 10.1002/advs.202100629

Figure 3.

Figure 3

Use of scRNA‐seq to characterize CD8 TIL subsets in lung tumors from A/J mice. A) Clustering of CD45+ immune cells. B) Clustering of CD45− cells including lung tumor cells. C) Clustering of intratumoral CD8+ T cells into the four indicated CD8 TIL subsets. D) The heatmap shows expression of the marker genes for the four tumor‐infiltrating CD8+ T cell states in the mice lung tumor CD8+ TILs. E) Let‐7b treatment increased the proportion of the EM‐like CD8+ TILs and decreased the proportion of exhausted and memory‐like CD8+ T cells in mouse lung (n = 2, p = 0.04, and p = 0.05, respectively).