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. 2021 Jul 8;8(17):2100629. doi: 10.1002/advs.202100629

Figure 5.

Figure 5

Suppression of PD‐1 and PD‐L1 expression in let‐7b‐treated mice. Predicted binding sites for let‐7b miRNA in human A) PD‐L1 mRNA and B) PD‐1 mRNA. scRNA‐seq was used to assess C) expression of PD‐L1 in CD45− tumor cells from let‐7b‐treated mice, and D) expression of PD‐1 in CD45+ immune cells from let‐7b‐treated mice. E) Efficacy of let‐7b in parental LKR13 cells or LKR13 shPD‐L1 KD cells. Data presented as mean ± SEM; n = 6; *p < 0.05 and ***p < 0.001. p‐values are calculated using one‐way ANOVA analysis.