Table 1. Eleven confirmed lead compounds.
Common names, IUPAC names, abbreviations, PubChem CID, and chemical structures of confirmed lead compounds listed in order of efficacy.
| Common and IUPAC names | Abbr. | PubChem CID | Structure |
|---|---|---|---|
| Warfarin 4-hydroxy-3-(3-oxo-1-phenylbutyl)chromen-2-one |
WAR | 54678486 |
|
| Cloxyquin 5-Chloro-8-hydroxyquinoline | CLO | 2817 |
|
| Ciclopirox olamine 2-aminoethanol;6-cyclohexyl-1-hydroxy-4-methylpyridin-2-one |
CPO | 38911 |
|
| Miconazole 1-[2-(2,4-dichlorophenyl)−2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole |
MIC | 4189 |
|
| Zinc pyrithione zinc;1-oxidopyridin-1-ium-2-thiolate | ZPT | 26041 |
|
| Dihydroartemisinin (4S,5R,9R,10S,12R,13R)−1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-ol |
DHA | 456410 |
|
| Chloroxine 5,7-dichloroquinolin-8-ol |
CHL | 2722 |
|
| Calcimycin 5-(methylamino)−2-[[(2S,3R,5R,8S,9S)−3,5,9-trimethyl-2-[1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]−1,7-dioxaspiro[5.5]undecan-8-yl]methyl]−1,3-benzoxazole-4-carboxylic acid |
CAL | 40486 |
|
| Sulindac 2-[(3Z)−6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid |
SUL | 1548887 |
|
| Artemesinin (1R,4S,5R,8S,9R,12S,13R)−1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-one |
ART | 68827 |
|
| Cortexolone (8R,9S,10R,13S,14S,17R)−17-hydroxy-17-(2-hydroxyacetyl)−10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one |
COR | 440707 |
|