Table 2. Summary of PubChem HTS and uHTS target-based screens of lead compound bioactivity.

Results of 13 target-based HTS screens, with '+' indicating inhibitory activity of lead compounds. Lead compound abbreviations: WAR, Warfarin; CLO, Cloxyquin; CPO, Ciclopirox olamine; MIC, Miconazole; ZPT, Zinc pyrithione; DHA, Dihydroartemisinin; CHL, Chloroxine; CAL, Calcimycin; SUL, Sulindac; ART, Artemisinin; COR, Cortexolone; POS, positive control. Other abbreviations: CI, confidence interval; Mtz, Metronidazole; PTU, N-phenylthiourea. Target abbreviations: Tdp1, Tyrosyl-DNA phosphodiesterase 1; Rorc, RAR-related orphan receptor gamma; AR, androgen receptor signaling pathway; TR, thyroid receptor signaling pathway; VDR, vitamin D receptor; ER, estrogen receptor alpha; AhR, aryl hydrocarbon receptor; GR, glucocorticoid receptor; Dopa, dopamine related; HIF1, Hypoxia-inducible factor 1-alpha; SHH, Sonic hedgehog; COX, cyclooxygenase.

Drug\path	Tdp1	Rorc	AR	TR	VDR	ER	AhR	GR	P53	Dopa	HIF1	SHH	COX
WAR									+
MIC	+	+		+	+		+
CLO	+	+	+	+	+	+				+
CPO	+	+	+	+	+	+		+	+	+
ZPT	+	+	+	+	+	+	+	+	+		+
DHA	+		+	+		+
CHL	+	+	+	+	+	+	+	+	+
CAL		+					+					+
SUL	+						+						+
ART	+									+
COR			+					+