Fig. 3.

Adaptive anti-VZV responses in APS-1 patients. A) VZV-specific IgG levels, shown as enzyme immunoassay units on a relative scale. B) VZV-specific IgG levels in patients without and with VZV reactivation. C) The number of cells producing IFN-γ in healthy controls and APS-1 patients (both with no reactivation and with VZV reactivation) in response to stimulation with inactivated VZV, measured by γ -IFN Elispot. The data are shown as spots per 200,000 cells. Healthy controls are indicated by open circles, APS-1 patients by filled circles. The mean level is indicated by the horizontal bars. The statistical significance of the difference was calculated using the Mann-Whitney U test.