Table 3. HR of death: univariate and multivariable analysis.
| Univariate analysis for probability of death non-adjusted for age group | |||||||
|---|---|---|---|---|---|---|---|
| Young (n = 263) |
MA (n = 6,325) |
Elderly (n = 5,896) |
|||||
| Variable | HR (CI 95%) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Sex | Women | 1 | 1 | 1 | |||
| Men | 1.11 (0.90–1.38) | 0.327 | 1.24 (1.19–1.30) | <0.001 | 1.19 (1.13–1.25) | <0.001 | |
| Education | Illiterate | 1 | 1 | 1 | |||
| Incomplete elementary | 0.57 (0.23–1.42) | 0.230 | 0.95 (0.86–1.06) | 0.372 | 0.93 (0.87–1.01) | 0.076 | |
| Complete elementary | 0.34 (0.13–0.85) | 0.021 | 0.84 (0.75–0.94) | 0.002 | 0.83 (0.77–0.90) | <0.001 | |
| High school | 0.38 (0.15–0.96) | 0.040 | 0.75 (0.66–0.84) | <0.001 | 0.82 (0.73–0.91) | <0.001 | |
| University education | 0.25 (0.09–0.68) | 0.007 | 0.65 (0.57–0.74) | <0.001 | 0.68 (0.60–0.77) | <0.001 | |
| Histological type | Squamous cell | 1 | 1 | 1 | |||
| Adenocarcinoma | 0.92 (0.68–1.24) | 0.571 | 0.91 (0.86–0.95) | <0.001 | 0.90 (0.85–0.94) | <0.001 | |
| Large cells | 1.02 (0.46–2.24) | 0.968 | 1.10 (0.96–1.28) | 0.179 | 1.26 (1.08–1.46) | 0.003 | |
| Other unspecified | 0.78 (0.54–1.12) | 0.181 | 1.21 (1.14–1.28) | <0.001 | 1.11 (1.04–1.17) | 0.001 | |
| CS | I/II | 1 | 1 | 1 | |||
| III | 2.84 (1.65–4.90) | <0.001 | 2.27 (2.10–2.45) | <0.001 | 1.94 (1.81–2.07) | <0.001 | |
| IV | 5.63 (3.35–9.47) | <0.001 | 3.67 (3.40–3.96) | <0.001 | 2.80 (2.62–3.00) | <0.001 | |
| Treatment | Surgery (± CT; ± RT; ± RT and CT; ± Other combinations) | 1 | 1 | 1 | |||
| RT (± CT; ± Other combinations) | 2.28 (1.66–3.13) | <0.001 | 2.23 (2.09–2.37) | <0.001 | 1.74 (1.63–1.86) | <0.001 | |
| CT (± Other combinations) | 2.35 (1.72–3.22) | <0.001 | 2.39 (2.23–2.55) | <0.001 | 2.04 (1.90–2.18) | <0.001 | |
| Other combinations | 1.25 (0.45–3.43) | 0.671 | 4.05 (3.42–4.81) | <0.001 | 3.62 (3.11–4.21) | <0.001 | |
| No treatment | 7.78 (5.12–11.84) | <0.001 | 7.52 (6.94–8.15) | <0.001 | 5.30 (4.91–5.71) | <0.001 | |
| Multivariable analysis for probability of death adjusted for age group | |||||||
|---|---|---|---|---|---|---|---|
| Young (n = 263) |
MA (n = 6,325) |
Elderly (n = 5,896) |
|||||
| Variable | HR (CI 95%) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| Sex | Women | 1 | 1 | 1 | |||
| Men | 1.08 (0.84–1.40) | 0.542 | 1.26 (1.20–1.33) | <0.001 | 1.22 (1.15–1.29) | <0.001 | |
| Education | Illiterate | 1 | 1 | 1 | |||
| Incomplete elementary | 0.42 (0.16–1.06) | 0.067 | 1.04 (0.94–1.17) | 0.429 | 0.99 (0.91–1.07) | 0.716 | |
| Complete elementary | 0.29 (0.11–0.76) | 0.011 | 0.94 (0.84–1.05) | 0.266 | 0.91 (0.84–0.99) | 0.031 | |
| High school | 0.31 (0.12–0.81) | 0.017 | 0.91 (0.80–1.03) | 0.130 | 0.89 (0.80–0.99) | 0.036 | |
| University education | 0.17 (0.06–0.49) | 0.001 | 0.81 (0.71–0.93) | 0.002 | 0.83 (0.73–0.94) | 0.004 | |
| Histological type | Squamous cell | 1 | 1 | 1 | |||
| Adenocarcinoma | 0.70 (0.48–1.02) | 0.062 | 0.91 (0.85–0.97) | 0.002 | 0.95 (0.89–1.01) | 0.095 | |
| Large cells | 0.47 (0.11–2.05) | 0.318 | 1.16 (0.97–1.39) | 0.094 | 1.37 (1.15–1.63) | <0.001 | |
| Other unspecified | 0.89 (0.56–1.40) | 0.610 | 1.11 (1.04–1.20) | 0.003 | 1.04 (0.97–1.12) | 0.257 | |
| CS | I/II | 1 | 1 | 1 | |||
| III | 3.24 (1.65–6.37) | 0.001 | 1.80 (1.63–1.99) | <0.001 | 1.70 (1.55–1.85) | <0.001 | |
| IV | 4.99 (2.54–9.81) | <0.001 | 2.86 (2.60–3.16) | <0.001 | 2.50 (2.29–2.73) | <0.001 | |
| Treatment | Surgery (± CT; ± RT; ± RT and CT; ± Other combinations) | 1 | 1 | 1 | |||
| RT (± CT; ± Other combinations) | 1.58 (1.05–2.39) | 0.027 | 1.66 (1.53–1.80) | <0.001 | 1.30 (1.19–1.42) | <0.001 | |
| CT (± Other combinations) | 1.56 (1.04–2.33) | 0.030 | 1.71 (1.57–1.86) | <0.001 | 1.41 (1.29–1.55) | <0.001 | |
| Other combinations | 1.69 (0.48–5.94) | 0.416 | 4.21 (3.32–5.34) | <0.001 | 3.94 (3.22–4.82) | <0.001 | |
| No treatment | 7.76 (4.26–14.16) | <0.001 | 5.43 (4.90–6.01) | <0.001 | 4.31 (3.91–4.76) | <0.001 | |
Note: HR: Hazard ratio; 95% CI: 95% confidence interval