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Schematic diagram of the role of miR-137 in the proliferation of PASMCs during hypoxia-induced pulmonary hypertension. Our study for the first time demonstrated that miR-137 is a novel regulator of proliferation of PASMCs in hypoxia-induced pulmonary hypertension by targeting calpain-2 pathway. DHPR: dihydropyridine receptor; RyR: ryanodine receptor; cADPR: CD38-cyclic ADP-ribose; IP3R: inositol 1,4,5-trisphosphate receptor; SERCA: sarco (endo) plasmic reticulum calcium ATPase.
