Table 3.
Recommended treatments for pediatric patients of M. pneumoniae pneumonia
| Drug | Route of administration | Drug dose (mg/kg/day), divided dose/day | Maximal dose | Treatment period | Age limit |
|---|---|---|---|---|---|
| Azithromycin | Oral or IV | Day 1, 10 mg/kg/day, #1; Day 2–5, 5 mg/kg/day, #1 | Day 1, 500 mg/day; Day 2–5, 250 mg/day | 3 Days | - |
| Clarithromycin | Oral or IV | 15 mg/kg/day, #2 | 1,000 mg/day | 10 Days | - |
| Roxithromycin | Oral | 5–8 mg/kg/day, #2 | 300 mg/day | 10 Days | - |
| Levofloxacin | Oral or IV | Oral: <5 years of age: 16–20 mg/kg/day, #2; ≥5 years of age: 8–10 mg/kg/day, #1; adolescents with mature musculoskeletal system, 500 mg/day, #1 | 750 mg/day | 7–14 Days (500 mg/day) | ≤18 Years of age |
| IV: <5 years of age: 16–20 mg/kg/day, #2; ≥5 years of age: 8–10 mg/kg/day, #1 | 5 Days (750 mg/day) | ||||
| Tosufloxacin | Oral | 12 mg/kg/ day, #2 | 360 mg/day | 7–14 Days | ≤18 Years of agea) |
| Doxycycline | Oral | 4 mg/kg/ day, #2 | 200 mg/day | 10 Days | <12 Years of ageb) |
| Minocycline | Oral or IV | 2–4 mg/kg/ day, #2 | 400 mg/day | 7–14 Days | <12 Years of ageb) |
IV, intravenous.
a)
Tosufloxacin is approved for pediatric use in Japan.
b)
Doxycycline and minocycline are approved for use in children ≥8 years of age in the United States.