Table 1.
Characteristics of the 50 convalescent healthcare workers and differences according to immune status at baseline and after response
| Overall (50) | Convalescent (27) | Infection‐naïve (23) | |
|---|---|---|---|
| Age (years) | 48 (39–59) | 45 (34–59) | 52 (44–60) |
| Sex (female) | 32 (64%) | 17 (63%) | 15 (65%) |
| Body mass index (kg m−2) | 23.3 (21.5–24.7) | 23.4 (21.8–24.6) | 23.1 (21.3–25.3) |
| Comorbidities (n, %) | 15 (30%) | 5 (19%) | 10 (43%) |
| Hypertension | 5 (10%) | 2 (7%) | 3 (13%) |
| Diabetes | 2 (4%) | – | 2 (9%) |
| SARS‐CoV‐2 RT‐PCR positive at diagnosis | 23 (46%) | 23 (85%) | – |
| Positive serology after diagnosis | 27 (54%) | 27 (100%) | |
| Positive serology at inclusiona | 18 (36%) | 18 (67%) | 0 |
| Median value (RU mL−1, IQR) | 6.3 (3–13.1) | 13.3 (7–33) | 4.5 (3–6.2) |
| Positive serology pre‐vaccinea | 12 (24%) | 12 (44%) | 0 |
| Median value (RU mL−1, IQR) | 5.5 (4–11.3) | 10.3 (4.7–30) | 4.3 (3.7–5.8) |
| Time from infection to vaccination (months) | 10.2 (10–10.4) | 10.2 (10–10.4) | – |
| Time from inclusion to vaccination (days) | 103 (90–112) | 104 (92–114) | 99 (83–109) |
| S‐specific serology (IgG) after 1st dose (AU mL−1) | 1569 (489–21468) | 18 895 (1793–40 000) | 663 (318–1335) |
| CD8+ T‐cell response to S (%) | |||
| Pre‐vaccination | 18 (36%) | 13 (48%) | 5 (22%) |
| After 1st dose | 40 (80%) | 22 (81%) | 18 (78%) |
| CD4+ T‐cell response to S (%) | |||
| Pre‐vaccination | 17 (34%) | 10 (37%) | 7 (30%) |
| After 1st dose | 36 (72%) | 21 (78%) | 15 (65%) |
Data are expressed as median and interquartile range (IQR), and percentage.
a
N‐specific serology.