Table 2.
Major etiological causes of secondary ITP.
| Secondary ITP | ||
|---|---|---|
| Vaccines | Influenza, poliomyelitis, pneumococcal, MMR, HPV, and HBV | [58] |
| Infections | HIV, HCV, CMV, DV, HV, AdVs, EBV, H. pylori, and TB | [28,29,55,74] |
| Drugs | NSAIDS, antibiotics, and antivirals | [75] |
| Connective tissue disease | LES, Sjogren, and APLS | [76] |
| Autoimmune thyroiditis | Basedow's and Hashimoto's diseases | [77,78] |
| Immunodeficiencies | CVID, IgA deficiency, DiGeorge's syndrome | [79,80] |
| Neoplasia | LNH and solid tumors (paraneoplastic) | [81,82] |
| Lymphoproliferative disorders | ALPS | [83] |
ITP: immune thrombocytopenic purpura; MMR: measles/mumps/rubella; HPV: human papillomavirus; HBV: hepatitis B virus; HIV: human immunodeficiency virus; HCV: hepatitis C virus; CMV: cytomegalovirus; DV: Dengue virus; HV: Hantavirus; AdV: Adenovirus; EBV: Epstein-Barr virus; TB: tuberculosis; NSAIDs: non-steroidal anti-inflammatory drugs; LES: Lupus erythematosus; APLS: anti-phospholipid syndrome; CVID: common variable immunodeficiency; LNH: non-Hodgkin's lymphoma; ALPS: autoimmune lymphoproliferative syndrome.