Fig. 4.

Differentially abundant species between patients treated for 7 days and 14 days. For each of the represented species, we report the significance of differences in the relative abundance between the 7-day and 14-day groups at a given time point (heat map on the left), the relative abundance in the groups (heat map in the middle) and the corresponding phylum and family (on the right). We reported species with differences in relative abundance between the 7- and 14-day groups associated with a significant Wilcoxon rank sum test (p < .05), a fold change ≥ 1.5 in the relative abundance and a mean relative abundance ≥ 0.05% in at least one of the compared groups. Finally, the species had to be detectable (relative abundance higher than 0) in at least 3 samples of one of the compared groups. Heat map on the left: coloured cells report significant differences (p < .05) associated with a ≥ 1.5 fold change in the relative abundance whereas white cells correspond to other cases. In particular, black represents the species significantly more abundant in the 7-day group whereas grey those significantly more abundant in the 14-day group. Heat map in the middle: square-root-transformed relative abundance is colour-scaled as indicated in the legend.