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. 2021 Feb 19;48(10):3089–3100. doi: 10.1007/s00259-021-05243-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7a — Intravital microscopy images of an untreated (control) and a sunitinib-treated Capan-2 pancreatic ductal adenocarcinoma xenograft. The tumor-bearing mice were given daily doses of 40 mg/kg sunitinib or vehicle for 4 days. b Density of small-diameter vessels (< 10 μm), density of large-diameter vessels (> 10 μm), vessel diameter, and vessel segment length versus time in untreated and sunitinib-treated Capan-2 tumors. c Hypoxic fraction in untreated and sunitinib-treated Capan-2 tumors. The hypoxic fractions were determined by immuohistochemistry using pimonidazole as a hypoxia marker. d Blood supply time (BST) image and BST histogram of an untreated and a sunitinib-treated Capan-2 tumor. The BST scale is given by the color bar. The vertical lines in the BST histograms show median BST. e BST in untreated and sunitinib-treated tumors. Points and columns, means of 6–8 tumors; bars, standard error (b-c and e). Fig. 6b-c and e was modified from Gaustad et al. [47]