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. 2021 Feb 19;48(10):3089–3100. doi: 10.1007/s00259-021-05243-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8a — A T₁-weighted magnetic resonance (MR) image of calibration phantoms (P) and a mouse bearing a window chamber (WC) with an A07-GFP melanoma xenograft (T), and a color-coded K^trans image of the A07-GFP tumor calculated from dynamic contrast-enhanced MR data by using Tofts generalized pharmacokinetic model. The K^trans scale is given by the color bar. b Intravital microscopy image of TRITC-dextran filled tumor vessels and blood supply time (BST) image of the A-07-GFP tumor. The BST scales are given by the color bar. c Median K^trans versus the density of all vessels and median K^trans versus the density of large-diameter vessels (> 20 μm) in A-07-GFP tumors. Points, individual tumors. Fig. 8c was modified from Gaustad et al. [14]