Table 1.
Overview of study design and risk of bias for each of the studies included in the systematic review
| Study | Prospective | Multi-centre | PET scanners used | EANM guidelines stated | SUV defined | Definition of prognostic factor provide | Follow up period | Separate validation cohort | Overall risk of bias |
|---|---|---|---|---|---|---|---|---|---|
| Adams [9] | N | N | Siemens Biograph 40 TruePoint | N | N |
PFS - relapse/progression/death attributable to PFS OS - Death from any cause |
Median: 994 days | N | Moderate |
| Aide [10] | N | N | Siemens Biograph TrueV | N | N | EFS - relapse/progression/unplanned treatment/death attributable to PFS | 2-year EFS | Y | High |
| Aide [11] | N | N | Siemens Biograph TrueV | Y | N |
PFS - relapse/progression OS - death from lymphoma or treatment |
Median: 25.7 months | N | Moderate |
| Akhtari [12] | N | N | GE Discovery ST GE Discovery RX GE Discovery STE | N | Y(bw) |
FFP - relapse or refractory disease OS - death from any cause |
Median: 4.96 years | N | Moderate |
| Albano [13] | N | Y | GE Discovery ST GE Discovery 690 | Y | N |
PFS - progression/relapse/death OS - death from any cause |
Median: 40 months | N | Moderate |
| Angelopulou [14] | N | N | Multiple not defined | N | N |
FFP - relapse or refractory disease OS - death from any cause |
Median: 56 months | N | High |
| Capobianco [15] | N | Y | Multiple1 | N | N | Not defined | Median: 5 years | Y | High |
| Ceriani [16] | N | Y | Multiple not defined | N | N | Not defined | Median: 64 months, 34 months | Y | High |
| Chang [17] | N | N | GE Discovery ST | N | N |
PFS - progression/relapse/death OS - death from any cause |
Median: 28.7 months | N | Moderate |
| Chang [18] | N | N | GE Discovery ST | N | N |
PFS - progression/relapse/death OS - death from any cause |
median 36 months | N | Moderate |
| Chihara [19] | N | N | GE Discovery LS | N | Y(bw) | PFS - progression/relapse/death from any cause OS - death from any cause | Median: 34.4 months | N | Moderate |
| Cottereau [20] | N | Y | Multiple not defined | N | N | Not defined | Median: 44 months | N | High |
| Cottereau [21] | N | Y | Multiple not defined | N | N |
PFS - progression/death from any cause OS - death from any cause |
Median: 55 months | Y | Moderate |
| Cottereau [22] | N | N | Siemens Biograph 16 | N | N | OS and PFS were defined according to the revised NCI criteria | Median: 64 months | N | Moderate |
| Decazes [23] | N | N | Siemens Biograph Sensation 16 HiRes | N | N | Both OS and PFS were defined according to the revised NCI criteria | Median: 44 months | N | Moderate |
| Esfahani [24] | N | N | Siemens Biograph | N | N | PFS - recurrence | Mean: 51 months | N | High |
| Gallicchio [25] | N | N | GE Discovery VCT GE Discovery LS VCT | N | N | Progression/disease-related death | Median: 18 months | N | High |
| Huang [26] | N | N | GE Discovery LS | N | Y(bw) |
PFS - progression/relapse/death OS - death from any cause |
Median: 30 months | N | Moderate |
| Ilyas [27] | N | N | GE Discovery ST GE Discovery VCT | N | N |
PFS - progression/death from any cause OS - death from any cause |
Median: 3.8 years | N | High |
| Jegadesh [28] | N | N | Not defined | N | N | Not defined | Median: 43.9 months | N | Moderate |
| Kanoun [29] | N | N |
Philips Gemini GXL Philips Gemini TOF |
N | N | PFS - progression/relapse/death from any cause | Median: 50 months | N | High |
| Kim [30] | N | N | Siemens Biograph 6 | N | N |
EFS - relapse/progression/stopping of treatment/death from any cause OS - death from any cause |
Median: 27.8 months | N | Moderate |
| Kim [31] | N | N |
Philips Gemini Siemens Biograph 40 |
N | N |
PFS - progression/relapse/death OS - death (? any cause) |
Median: 25.8 months | N | Moderate |
| Kwon [32] | N | Y | GE Discovery ST | N | Y(bw) |
PFS - progression/relapse/death from any cause OS - death from any cause |
Median: 30.8 months | N | High |
| Lanic [33] | N | Y | Siemens Biograph LSO Sensation 16 | N | N |
PFS - progression/relapse/death from any cause OS - death from any cause |
Median: 28 months | N | High |
| Lue [34] | N | N | GE Discovery ST | N | N |
PFS - progression/relapse/death from any cause OS - death from any cause |
Median: 48 months | N | Moderate |
| Mettler [35] | N | Y | Multiple not defined | N | N |
PFS - progression/relapse/death from any cause OS - death from any cause |
Not defined | N | High |
| Mikhaeel [36] | N | N | GE Discovery ST GE Discovery VCT | N | N |
PFS - progression/death from any cause OS - death |
Median: 3.8 years | N | Moderate |
| Milgrom [37] | N | N | GE Discovery ST GE Discovery RX GE Discovery STE | N | N | Relapse or progression or death | Not defined | Y | High |
| Miyazaki [38] | N | N | GE Discovery STE | N | N |
PFS - relapse/death from any cause OS - death |
Median: 32.7 months | N | Moderate |
| Park [39] | N | N | GE Discovery LS, GE Discovery STE | N | N |
PFS - progression/relapse/death from any cause OS - death from any cause |
Median: 21 months | N | High |
| Sasanelli [40] | N | Y |
Philips Gemini GXL Siemens Biograph 2 GE Discovery ST |
N | Y(bw) |
PFS - relapse OS - death from any cause |
Median: 39 months | N | Moderate |
| Senjo [41] | N | Y |
Philips Gemini GXL GE Discovery ST |
Y | Y(bw) |
PFS - progression/relapse/death OS - death |
Median: 33.1 months, 32.8 months | Y | High |
| Song [42] | N | Y | Siemens Biograph | N | N | PFS progression OS - death from any cause | Median: 40.8 months | Y | Moderate |
| Song [43] | N | Y | Siemens Biograph | N | N | Not defined | Median: 45.8 months | N | Moderate |
| Song [44] | N | Y | Siemens Biograph | N | N |
PFS progression, death related to lymphoma OS - death from any cause |
Median: 36 months | N | Moderate |
| Toledano [45] | N | N | Siemens Biograph Sensation 16 HiRes | N | N | OS and PFS were defined according to the revised NCI criteria | Median: 40 months | N | Moderate |
| Tseng [46] | N | N | GE Discovery LS | N | N | Not defined | Median: 50 months | N | High |
| Xie [47] | N | N | Siemens Biograph 64 | Y | N | PFS - progression/relapse/death from any cause | Median: 17 months | N | High |
| Zhang [48] | N | N | Siemens Biograph 64 | N | N | PFS - progression, death related to lymphoma | Median: 34 months | N | Moderate |
| Zhou [49] | N | N | GE Discovery ST Siemens Biograph 64 | N | N | N - not defined | Median: 30 months | N | Moderate |
PFS progressive free survival; EFS event free survival; OS overall survival; FFP free from progression; bw body weight; 1 Discovery 690, STE, ST, RX, 600, 710, LS, Biograph HiRez, Truepoint, mCT, LSO, BGO and Gemini TF and GXL; EANM European Association of Nuclear Medicine