Skip to main content
. 2021 Aug 24;24(9):103020. doi: 10.1016/j.isci.2021.103020

Figure 3.

Figure 3

PD-1 regulates most of the genes affected by the antigen receptor

(A) Venn diagram classifying the groups of genes between stimulation with anti-CD3 and anti-CD28 antibodies to stimulation with anti-CD3, anti-CD28 antibodies, and PD-Ls.

(Bi) Venn diagrams displaying the number of PD-1-regulated DEGs across the three subsets of T cells.

(Bii) Quantification of the previous experiment highlighting the proportion of antigen receptor affected genes that were regulated by either PD-L1 or PD-L2 in each of the T cell subsets.

(Ci) Venn diagrams showing the common and the diverse genes between the different subsets in cell stimulated with anti-CD3 and anti-CD28 antibodies.

(Cii) Comparison between the proportion of PD-1-regulated DEGs out of the genes that were shared between the subsets vs. the genes that were specific to only one of the subsets.