Figure 7.

PD-1 signaling-induced STAT1 and STAT2 upregulation correlates with clinical response to checkpoint blockade

(A and B) Upregulated PD-1 induced genes were analyzed using ReMap project data (A) and Mean Rank score (B) to predict specific transcription factors across the different subset and the experiential conditions that might regulated key genes in the relevant groups.

(C) Heatmap showing the relative expression of key transcription factors through the different experimental conditions.

(D) Curated single cell data was used to calculate the expression of STAT1 and STAT2 among melanoma patients the either responded, or not to PD-1 blockade.

(E) Kaplan Myer plots showing 5-year survival of patient with lung adenocarcinoma in relation to STAT1 expression in the tumor tissue, and in different immune compartments. See also Figure S3.