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. 2021 Mar 15;39(5):1366–1374. doi: 10.1007/s10637-021-01085-7

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© The Author(s) 2021

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Fig. 1 — Waterfall plot depicting best percent changes in target tumor burden. All patients harbored PI3K aberrations, except for patients with breast cancer harboring AKT E17K* mutations. Two patients with clinical progression were excluded from this graph. Seven subjects did not undergo subsequent follow-up of tumor markers. Abbreviations: NSCLC, non-small cell lung cancer; NGG, next-generation sequencing; PI3K/Akt, phosphatidylinositol 3-kinase/protein kinase B; NA, not applicable (no follow-up of tumor markers for assessment)