Table 2.

Incidence of treatment-related adverse events

Treatment-related adverse events	Grade 1	Grade 2	Grade 3	Grade 4	All grades
Any event	7 (54 %)	17 (100 %)	2 (15 %)	1 (8 %)	27 (100 %)
Anorexia	1 (8 %)	2 (15 %)	1 (8 %)	0 (0 %)	4 (36 %)
Constipation	0 (%)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Diarrhea	1 (8 %)	1 (8 %)	0 (0 %)	0 (0 %)	2 (15 %)
Nausea	1 (8 %)	1 (8 %)	0 (0 %)	0 (0 %)	2 (15 %)
Mucositis	1 (8 %)	0 (0 %)	0 (0 %)	0 (0 %)	1 (8 %)
Skin rash	2 (15 %)	2 (15 %)	0 (0 %)	0 (0 %)	4 (36 %)
Itching	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Fatigue	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Headache	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Back pain	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Shoulder pain	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Dyspnea	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Pneumonia	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Pulmonary thromboembolism	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)
Hyperglycemia	1 (8 %)	1 (8 %)	1 (8 %)	1 (8 %)	4 (36 %)
Neutropenia	0 (0 %)	1 (8 %)	0 (0 %)	0 (0 %)	1 (8 %)

NOTE. Adverse events were those with onset after enrolment to last follow-up after disease progression