Table 3.

Comparison of unbound brigatinib plasma pharmacokinetic parameters

Parameter	Comparison	LS Mean (SE)	Geometric LS Mean Ratio (90 % CI)
Cmax,u (ng/mL)	Severe renal impairment vs. Normal renal function	0.130 (0.1330)	1.14 (0.90–1.44)
AUC0 − last,u (h·ng/mL)		0.572 (0.1229)	1.77 (1.43–2.20)
AUC0−∞,u (h·ng/mL)		0.652 (0.1311)	1.92 (1.52–2.42)

AUC_0−∞,u, unbound area under the plasma concentration-time curve from time zero to infinity; AUC_{0 − last,u}, unbound area under the plasma concentration-time curve from time zero to the time of the last measurable concentration; CI, confidence interval; C_max,u, unbound maximum observed plasma concentration; LS, least squares; SE, standard error