Table 4.
Diagnostic performance of PET/CT parameters in discriminating positive versus negative lymph nodes at histopathology
| Characteristics | Area under ROC curve estimate (95% CI) | Cut-off, Youden index* | Sensitivity % (95% CI) | Specificity % (95% CI) | Accuracy % (95% CI) | PPV % (95% CI) | NPV % (95% CI) | TP | TN | FN | FP | Total |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All cases | ||||||||||||
| Groin parameters | ||||||||||||
| Visual assessment | – | – | 85.6 (78.3–92.8) | 65.5 (59.0–72.0) | 71.6 (66.5–76.8) | 52.0 (44.0–60.1) | 91.2 (86.7–95.8) | 77 | 135 | 13 | 71 | 296 |
| Overall assessment | – | – | 78.9 (70.5–87.3) | 78.2 (72.5–83.8) | 78.4 (73.7–83.1) | 61.2 (52.3–70.1) | 89.4 (85.0–93.9) | 71 | 161 | 19 | 45 | 296 |
| LN-SUVmax | 0.83 (0.77–0.89) | 1.89, 0.58 | 73.3 (64.2–82.5) | 85.0 (80.1–89.8) | 81.4 (77.0–85.8) | 68.0 (58.8–77.3) | 87.9 (83.4–92.5) | 66 | 175 | 24 | 31 | 296 |
| Pelvic parameters | ||||||||||||
| Visual assessment | – | – | 75.0 (50.5–99.5) | 66.7 (49.8–83.5) | 69.0 (55.1–83.0) | 47.4 (24.9–69.8) | 87.0 (73.2–100.0) | 9 | 20 | 3 | 10 | 42 |
| Overall assessment | – | – | 75.0 (50.5–99.5) | 66.7 (49.8–83.5) | 69.0 (55.1–83.0) | 47.4 (24.9–69.8) | 87.0 (73.2–100.0) | 9 | 20 | 3 | 10 | 42 |
| LN-SUVmax | 0.84 (0.72–0.97) | 2.03, 0.52 | 75.0 (50.5–99.5) | 76.7 (61.5–91.8) | 76.2 (63.3–89.1) | 56.3 (31.9–80.6) | 88.5 (76.2–100.7) | 9 | 23 | 3 | 7 | 42 |
| cN0 patients | ||||||||||||
| Groin parameters | ||||||||||||
| Visual assessment | 62.5 (43.1–81.9) | 71.1 (63.9–78.4) | 69.9 (63.1–76.8) | 25.9 (14.6–37.1) | 92.2 (87.3–97.1) | 15 | 106 | 9 | 43 | 173 | ||
| Overall assessment | 54.2 (34.2–74.1) | 83.9 (78.0–89.8) | 79.8 (73.8–85.8) | 35.1 (19.8–50.5) | 91.9 (87.3–96.5) | 13 | 125 | 11 | 24 | 173 | ||
| LN-SUVmax | 0.62 (0.46–0.78) | 1.80, 0.34 | 45.8 (25.9–65.8) | 87.9 (82.7–93.2) | 82.1 (76.4–87.8) | 37.9 (20.3–55.6) | 91.0 (86.3–95.7) | 11 | 131 | 13 | 18 | 173 |
ROC, receiver operating characteristic; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; TP, true positive; TN, true negative; FN, false negative; FP, false positive; LN, lymph node
*According to ref. [28]