Table 3.
Summary of ROC curve analysis for each potential biomarker as calculated for AUC of peaks within associated m/z ranges. A peak area threshold is listed for each potential biomarker which optimizes sensitivity and specificity for the MALDI-ToF protocol when compared to COVID-19 status.
| Potential biomarkerm/z range | Peak area threshold | AUC-ROC | Sensitivity (%) | Specificity (%) |
|---|---|---|---|---|
| Gargle marker | >5789021.2 | 0.548 | 40 | 76 |
| (11,140–11,160 m/z) | ||||
| Ig light chains | >4629948.3 | 0.756 | 70 | 80 |
| (23,500–23,800 m/z) | ||||
| (Ig Heavy chain/Amylase)+2 | >4368750.1 | 0.941 | 96.67 | 90 |
| (27,900–29,400 m/z) | ||||
| Ig Heavy chain/Amylase | >38684701.8 | 0.961 | 96.67 | 90 |
| (55,500–59,000 m/z) | ||||
| Spike protein S2 | >1429133.2 | 0.976 | 100 | 93.33 |
| (66,400–68,100 m/z) | ||||
| Spike protein S1 | >937903.9 | 0.954 | 93.33 | 90 |
| (78,600–80,500 m/z) | ||||
| Asymptomatic biomarker | >1104743.1 | 0.933 | 93.33 | 90 |
| (111,500–115,500 m/z) |