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. 2021 Sep 9;40(42):6130–6138. doi: 10.1038/s41388-021-02005-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Spliceosome is among the top significant pathways involving upregulated genes in newly diagnosed MM compared with healthy controls from GSE110486. B Gene enrichment plot for spliceosome pathway genes in MM samples compared with healthy controls from GSE110486. NES, normalized enrichment score. C Serine and arginine-rich splicing factor (SRSF) gene expression was associated with shorter overall survival time in MM; results were obtained from 767 newly diagnosed multiple myeloma (NDMM) patients in the MMRF cohort. D Comparison of the number of IR events in primary MM samples from MMRF (n = 767) compared with normal plasma cell samples from GEO (n = 13). Violin plots show the median and 25th and 75th percentiles (box) and the 95% confidence interval (whiskers). P value was determined using the Mann-Whitney test.