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. 2021 Sep 9;40(42):6130–6138. doi: 10.1038/s41388-021-02005-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Gene ontology enrichment analysis of genes harboring MM-specific IR events in specialized biological processes. B Scatter plot showing the number of IR events vs. IR-neoAg load in NDMM patients in the MMRF cohort. Each dot represents an individual patient (N = 767). Spearman correlation rho = 0.97, p value < 0.0001. C Scatterplot showing HLA allele frequency vs. the number of predicted IR-neoAgs bound in MMRF NDMM samples. D Top 20 most abundant IR-neoAg peptides and the number of HLA alleles in the MMRF NDMM samples predicted to bind each peptide; numbers in each bar represent the quantity of HLA allele subtypes.