Table 1.

Univariate and multivariate Cox regression analysis of OS in newly diagnosed MM.

	Univariate analysis			Multivariate analysis
	HR	95% CI of HR	P value	HR	95% CI of HR	P value
Variable
IR-neoantigen (high/low)	1.431	1.041–1.968	0.027	1.622	1.056–2.492	0.027
Age (years)	1.038	1.021–1.055	<0.001	1.046	1.023–1.069	<0.001
Sex (male/female)	1.536	1.089–2.165	0.014	1.537	0.954–2.476	0.077
Stage
ISS Stage (I/II/III)	2.038	1.640–2.532	<0.001	1.442	0.963–2.159	0.076
Revised ISS Stage	2.398	1.760–3.266	<0.001	1.496	0.865–2.588	0.15
TP53 status
TP53_Loss	1.088	0.823–1.438	0.555	1.343	0.806–2.238	0.257
BI_TP53	0.622	0.450–0.859	0.004	0.652	0.206–2.062	0.467
NS_TP53	2.755	1.603– 4.732	<0.001	1.153	0.145–9.146	0.893

IR-neoantigen, Intron retention-derived neoantigen, ISS stage Myeloma International Staging System, HR Hazard ratio, CI confidence interval, Revised Stage (R-ISS) was calculated as defined by the International Myeloma Working Group, by considering LDH, β2-microglobulin, albumin, deletion of chromosome 17p, and translocations; TP53_Loss: TP53 copy number variation; BI_TP53: bi-allelic p53 status; NS_TP53: presence of nonsynonymous mutation on TP53.

Bold values indicate p values < 0.05. Multivariate analysis p-value for age is 0.00006.