TABLE 3.

Univariate and multivariate analyses of overall survival.

Characteristics	Univariate			Multivariate
	HR	95% CI	p value	HR	95% CI	p value
COL7A1 immunohistochemistry score			0.011			0.121
≥8 versus <8	1.81	1.15–2.87
COL7A1 site of expression			0.001			0.003
Intracellular versus Extracellular	2.07	1.32–3.25		2.00	1.26–3.16
Age	0.99	0.98–1.01	0.403
Sex			0.479
Male versus Female	0.84	0.53–1.35
Tumor location			<0.001			0.613
Middle versus Lower	1.17	0.61–2.24
Upper versus Lower	1.46	0.82–2.59
Whole versus Lower	4.44	2.38–8.29
Tumor size, cm	1.08	1.02–1.14	0.006			0.732
Gross type			<0.001			0.001
Borrmann type IV versus Other	3.74	2.19–6.38		2.63	1.48–4.69
Histologic type			0.442
Undifferentiated versus Differentiated	1.21	0.74–1.97
Lauren			0.009			0.904
Diffuse versus Intestinal	2.19	1.31–3.65
Other versus Intestinal	1.45	0.73–2.86
Depth of invasion			<0.001			0.002
T3 versus T2	1.91	0.63–5.69		1.35	0.45–4.08
T4 versus T2	6.18	2.24–17.07		3.37	1.18–9.62
LN metastasis			<0.001			0.079
N1 versus N0	0.58	0.19–1.76		0.58	0.18–1.82
N2 versus N0	0.80	0.31–2.06		0.88	0.32–2.37
N3 verssus N0	2.38	1.13–5.01		1.59	0.71–3.55
Distant metastasis			<0.001			0.186
M1 versus M0	3.13	1.80–5.44
Pathologic stagea			<0.001			0.815
II versus I	2.77	0.35–21.86
III versus I	5.37	0.74–38.85
IV versus I	13.91	1.84–105.06
Lymphatic invasion			0.002			0.025
Present versus Absent	2.83	1.45–5.49		2.26	1.11–4.61
Venous invasion			0.005			0.104
Present versus Absent	1.98	1.23–3.19
Perineural invasion			0.002			0.351
Present versus Absent	2.19	1.33–3.59

^aAccording to the eighth edition of the American Joint Committee on Cancer Classification

CI confidence interval, HR hazard ratio, LN lymph node.