Figure 5.

Spatial and temporal variation in parameter measurements throughout U87 tumor progression. With progression, tumor volume increases. The spatial distribution is reflected as distance from tumor margin (0 is tumor margin, 1 is center of tumor). Cellularity (ADC), vascularity (F_p, K^trans, v_e, v_p from DCE) and metabolism (pH_e from BIRDS) as well as quantitative T₂ and pre/post-contrast T₁ parameter values are included. All imaging voxels across all timepoints and all tumors were fit to a 2^nd order polynomial to illustrate the changing spatial parameter distributions with tumor progression.