Table 2:

Pharmacokinetic parameters of bupropion (BUP) and its metabolites as determined in the second and third trimester of pregnancy when compared with 6–12 weeks postpartum in the same subjects

	Parameter	T2 vs Matched Postpartum (n=5)			T3 vs Matched Postpartum (n=5)
		T2	PP	P-Value	T3	PP	P-Value
BUP	Css (μM/g)	0.33 [0.08–1.2]	0.53 [0.11–1.3]	0.4787	0.44 [0.19–1.2]	0.41 [0.11–1.1]	0.8056
	CLR (L/h)	2.4 [0.77–6.4]	1.1 [0.09–18.5]	0.4548	1.8 [0.26–11.8]	1.9 [0.26–18.5]	0.97
OH-BUP	Css OH-BUP (μM/g)	15.1 [10.6–18.7]	16.3 [4.9–39.6]	0.7839	16.5 [6.3–30.9]	13.3 [4.9–39.6]	0.6896
	CLR (L/h)	0.20 [0.11–0.36]	0.10 [0.02–0.54]	0.2937	0.08 [0.04–0.12]	0.10 [0.03–0.46]	0.5539
	CLf (L/h)	50.7 [9.9–400.9]	13.4 [1.7–120.8]	0.1619	24.9 [5.8–71.2]	15.9 [3.1–120.8]	0.228
S,S-OH-BUP	Css (μM/g)	0.73 [0.20–1.4]	0.78 [0.10–2.2]	0.7772	0.83 [0.36–1.7]	0.64 [0.10–2.2]	0.4699
	CLR (L/h)	0.93 [0.31–3.4]	0.35 [0.09–3.5]	0.1707	0.40 [0.24–0.72]	0.47 [0.09–3.5]	0.7751
	SS-OH-BUP/ BUP	2.2 [1.0–6.0]	1.5 [0.7–5.9]	0.4729	1.9 [0.9–8.7]	1.6 [0.8–5.9]	0.4943
R,R-OH-BUP	Css (μM/g)	15.8 [10.0–22.2]	15.9 [5.5–35.7]	0.9786	13.7 [5.9–21.2]	14.0 [5.5–35.7]	0.9647
	CLR (L/h)	0.15 [0.07–0.32]	0.08 [0.02–0.45]	0.3564	0.07 [0.05–0.09]	0.09 [0.03–0.35]	0.6659
	RR-OH-BUP/ BUP	43.8 [16.4–178.7]	32.5 [15.8–77.2]	0.5907	33.7 [13.5–99.1]	35.6 [15.2–77.2]	0.8544
Threo	Css (μM/g)	3.4 [1.8–6.7]	4.1 [1.2–10.8]	0.4896	4.9 [3.1–10.7]	4.7 [1.2–10.8]	0.8675
	CLR (L/h)	3.9 [1.7–8.6]	2.4 [0.55–17.6]	0.381	2.0 [1.1–2.8]	2.9 [0.59–17.6]	0.5748
	CLf (L/h)	89.4 [20.1–275.8]	34.5 [2.9–166.4]	0.2477	56.6 [17.0–208.0]	68.5 [15.8–166.4]	0.5949
	Threo/ BUP	10.3 [4.8–23.1]	7.8 [3.5–17.6]	0.545	11.2 [5.6–16.6]	11.5 [9.7–17.6]	0.8878
Erythro	Css (μM/g)	0.49 [0.33–0.78]	0.67 [0.25–1.7]	0.2739	0.63 [0.52–0.79]	0.80 [0.25–1.7]	0.4832
	CLR (L/h)	2.1 [0.91–4.4]	1.6 [0.36–9.7]	0.5107	1.2 [0.74–1.7]	1.9 [0.36–9.7]	0.4811
	CLf (L/h)	23.8 [3.9–105.8]	10.6 [1.3–70.7]	0.3067	17.9 [4.1–112.1]	21.1 [4.9–70.7]	0.5992
	Erythro/ BUP	1.5 [0.4–4.2]	1.3 [0.5–3.2]	0.771	1.4 [0.6–2.7]	1.9 [1.2–3.2]	0.1358
Threo-OH	CLf (L/h)	2.4 [0.4–12.4]	1.2 [0.4–4.9]	0.0809	1.7 [0.2–8.9]	1.7 [0.4–4.9]	0.9983
Erythro-OH	CLf (L/h)	10.8 [3.2–39.8]	5.1 [1.7–20.8]	0.025	9.4 [2.5–36.7]	7.6 [2.6–20.8]	0.556
4’OH-BUP	CLf (L/h)	1.5 [0.1–28.2]	0.7 [0.0–5.7]	0.6186	0.8 [0.1–4.8]	1.0 [0.3–5.7]	0.3921

OH-BUP, hydroxybupropion; Threo, threohydrobupropion; Erythro, erythrohydrobupropion; 4’OH-BUP, 4’-hydroxy-bupropion; T2, second trimester; T3, third trimester; PP, postpartum (defined as 6–12 weeks after delivery)

Values shown above include the geometric mean and [range]. Data were log-transformed for analysis with paired t-test

Steady-state concentrations (Css) are presented as dose-normalized.