Table 5.
Significant ontology terms resulting from the analysis of the 817 genes shared by PB, PB.NLS-1–558, Mm523 and Hs524.
| GO ID | GO Term | P Value* | Nr. Genes |
|---|---|---|---|
| Fused GO terms: synapse organization (6,51% genes) | |||
| G0:0034330 | cell junction organization | 0,001312 | 49 |
| G0:0034329 | cell junction assembly | 0,023703 | 32 |
| G0:0050808 | synapse organization | 0,000431 | 36 |
| G0:0099173 | postsynapse organization | 0,005316 | 19 |
| G0:0099084 | postsynaptic specialization organization | 0,013763 | 8 |
| Fused GO terms: regulation of small GTPase mediated signal transduction (14.61% genes) | |||
| G0:0044093 | positive regulation of molecular function | 0,018196 | 92 |
| G0:0007264 | small GTPase mediated signal transduction | 0,004348 | 40 |
| G0:0008047 | enzyme activator activity | 0,013464 | 37 |
| G0:0043087 | regulation of GTPase activity | 0,000939 | 37 |
| G0:0060589 | nucleoside-triphosphatase regulator activity | 0,000800 | 30 |
| G0:0030695 | GTPase regulator activity | 0,000726 | 28 |
| G0:0043547 | positive regulation of GTPase activity | 0,022595 | 30 |
| G0:0051056 | regulation of small GTPase mediated signal transduction | 0,000102 | 31 |
| G0:0005096 | GTPase activator activity | 0,000898 | 26 |
| Fused GO terms:nervous system development (37.32% genes) | |||
| G0:0007275 | multicellular organism development | 0,000027 | 238 |
| G0:0009653 | anatomical structure morphogenesis | 0,000016 | 139 |
| G0:0060322 | head development | 0,002424 | 53 |
| G0:0000902 | cell morphogenesis | 0,000148 | 67 |
| G0:0032989 | cellular component morphogenesis | 0,001750 | 52 |
| G0:0048468 | cell development | 0,006713 | 107 |
| G0:0048731 | system development | 0,000513 | 212 |
| G0:0051128 | regulation of cellular component organization | 0,020339 | 114 |
| G0:2000026 | regulation of multicellular organismal development | 0,048972 | 100 |
| G0:0048513 | animal organ development | 0,035004 | 158 |
| G0:0000904 | cell morphogenesis involved in differentiation | 0,004732 | 49 |
| G0:0007399 | nervous system development | 0,000000 | 142 |
| G0:0007417 | central nervous system development | 0,000026 | 69 |
| G0:0022008 | neurogenesis | 0,000002 | 99 |
| G0:0051960 | regulation of nervous system development | 0,001844 | 59 |
| G0:0120036 | plasma membrane bounded cell projection organization | 0,000084 | 88 |
| G0:0007420 | brain development | 0,005967 | 50 |
| G0:0120035 | regulation of plasma membrane bounded cell projection organization | 0,023390 | 44 |
| G0:0048699 | generation of neurons | 0,000001 | 96 |
| G0:0120039 | plasma membrane bounded cell projection morphogenesis | 0,000663 | 48 |
| G0:0030182 | neuron differentiation | 0,000000 | 90 |
| G0:0048666 | neuron development | 0,000141 | 71 |
| GO:0045664 | regulation of neuron differentiation | 0,047755 | 42 |
| GO:0031175 | neuron projection development | 0,000310 | 64 |
| GO:0048667 | cell morphogenesis involved in neuron differentiation | 0,001687 | 43 |
| GO:0016358 | dendrite development | 0,043162 | 22 |
| GO:0061564 | axon development | 0,013767 | 37 |
| GO:0007409 | axonogenesis | 0,010504 | 35 |
*
Term PValue corrected with Bonferroni step down. GO terms related to neurogenesis and neuron