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. 2021 Aug 26;12:721013. doi: 10.3389/fimmu.2021.721013

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Copyright © 2021 Luo, Xue, Mao, Lin, Tang, Song, Liu, Tong, Hou, Huang, Ouyang, Wang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The performance of HLA-DR on MTB-specific cells in distinguishing ATB patients from LTBI individuals in Caidian cohort. (A) Aligned dot plots showing HLA-DR expression on MTB-specific cells in ATB patients and LTBI individuals. Horizontal lines indicate the medians. (B) ROC analysis showing the performance of HLA-DR expression on MTB-specific cells in discriminating ATB patients from LTBI individuals. (C) Aligned dot plots showing the proportions of HLA-DR⁺CD27^- cells of MTB-specific cells in ATB patients and LTBI individuals. Horizontal lines indicate the medians. (D) ROC analysis showing the performance of the proportion of HLA-DR⁺CD27^- cells of MTB-specific cells in discriminating ATB patients from LTBI individuals. (E) Aligned dot plots showing the proportions of HLA-DR^-CD27⁺ cells of MTB-specific cells in ATB patients and LTBI individuals. Horizontal lines indicate the medians. (F) ROC analysis showing the performance of the proportion of HLA-DR^-CD27⁺ cells of MTB-specific cells in discriminating ATB patients from LTBI individuals. **P < 0.01, ***P < 0.001 (Mann-Whitney U test). MTB, Mycobacterium tuberculosis; ATB, active tuberculosis; LTBI, latent tuberculosis infection; AUC, area under the curve.