Table 2.
The performance of HLA-DR on MTB-specific cells for distinguishing between ATB and LTBI in Qiaokou cohort.
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| HLA-DR on IFN-γ+ cells (%) | 17 | 0.662 (0.549–0.775) | 57.50% (42.19–71.49%) | 65.31% (51.31–77.08%) | 57.50% (42.19–71.49%) | 65.31% (51.31–77.08%) | 1.66 (1.04–2.65) | 0.65 (0.43–0.98) | 61.80% |
| HLA-DR on TNF-α+ cells (%) | 38 | 0.880 (0.804–0.956) | 85.71% (70.63–93.74%) | 77.78% (63.73–87.46%) | 75.00% (59.81–85.81%) | 87.50% (73.89–94.54%) | 3.86 (2.2–6.77) | 0.18 (0.08–0.42) | 81.25% |
| HLA-DR on IL-2+ cells (%) | 43 | 0.824 (0.728–0.920) | 82.86% (67.32–91.90%) | 74.42% (59.76–85.07%) | 72.50% (57.17–83.89%) | 84.21% (69.58–92.56%) | 3.24 (1.9–5.51) | 0.23 (0.11–0.49) | 78.21% |
| HLA-DR on IFN-γ+TNF-α+ cells (%) | 48 | 0.909 (0.843–0.974) | 84.38% (68.25–93.14%) | 82.05% (67.33–91.02%) | 79.41% (63.20–89.65%) | 86.49% (72.02–94.09%) | 4.7 (2.36–9.35) | 0.19 (0.08–0.43) | 83.10% |
| HLA-DR on IFN-γ+IL-2+ cells (%) | 51 | 0.889 (0.812–0.967) | 75.00% (57.89–86.75%) | 86.11% (71.34–93.92%) | 82.76% (65.45–92.40%) | 79.49% (64.47–89.22%) | 5.40 (2.34–12.48) | 0.29 (0.16–0.54) | 80.88% |
| HLA-DR on TNF-α+IL-2+ cells (%) | 44 | 0.901 (0.833–0.969) | 93.75% (79.85–98.27%) | 72.97% (57.02–84.60%) | 75.00% (59.81–85.81%) | 93.10% (78.04–98.09%) | 3.47 (2.03–5.93) | 0.09 (0.02–0.33) | 82.61% |
| HLA-DR on IFN-γ+TNF-α+IL-2+ cells (%) | 51 | 0.902 (0.831–0.972) | 77.42% (60.19–88.61%) | 84.85% (69.08–93.35%) | 82.76% (65.45–92.40%) | 80.00% (64.11–89.96%) | 5.11 (2.23–11.71) | 0.27 (0.14–0.52) | 81.25% |
MTB, Mycobacterium tuberculosis; ATB, active tuberculosis; LTBI, latent tuberculosis infection; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.