Table 3.
The performance of HLA-DR on MTB-specific cells for distinguishing between ATB and LTBI in Caidian cohort.
| Variables | Cutoff value | AUC (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | PPV (95% CI) | NPV (95% CI) | PLR (95% CI) | NLR (95% CI) | Accuracy |
|---|---|---|---|---|---|---|---|---|---|
| HLA-DR on IFN-γ+ cells (%) | 17 | 0.510 (0.364–0.657) | 39.29% (23.56–57.59%) | 60.00% (43.57–74.45%) | 44.00% (26.66–62.93%) | 55.26% (39.71–69.85%) | 0.98 (0.53–1.81) | 1.01 (0.68–1.51) | 50.79% |
| HLA-DR on TNF-α+ cells (%) | 38 | 0.824 (0.723–0.924) | 76.92% (57.95–88.97%) | 65.71% (49.15–79.17%) | 62.50% (45.25–77.07%) | 79.31% (61.61–90.16%) | 2.24 (1.35–3.72) | 0.35 (0.17–0.74) | 70.49% |
| HLA-DR on IL-2+ cells (%) | 43 | 0.881 (0.793–0.970) | 81.82% (61.48–92.70%) | 70.97% (53.41–83.91%) | 66.67% (47.82–81.36%) | 84.62% (66.47–93.85%) | 2.82 (1.57–5.06) | 0.26 (0.1–0.64) | 75.47% |
| HLA-DR on IFN-γ+TNF-α+ cells (%) | 48 | 0.891 (0.811–0.972) | 82.61% (62.86–93.02%) | 69.70% (52.66–82.63%) | 65.52% (47.35–80.06%) | 85.19% (67.52–94.09%) | 2.73 (1.57–4.73) | 0.25 (0.1–0.63) | 75.00% |
| HLA-DR on IFN-γ+IL-2+ cells (%) | 51 | 0.938 (0.876–1.000) | 90.48% (71.09–97.35%) | 83.33% (66.44–92.67%) | 79.17% (59.53–90.76%) | 92.59% (76.63–97.95%) | 5.43 (2.41–12.23) | 0.11 (0.03–0.43) | 86.27% |
| HLA-DR on TNF-α+IL-2+ cells (%) | 44 | 0.892 (0.806–0.978) | 90.91% (72.19–97.47%) | 68.97% (50.77–82.73%) | 68.97% (50.77–82.73%) | 90.91% (72.19–97.47%) | 2.93 (1.68–5.12) | 0.13 (0.03–0.51) | 78.43% |
| HLA-DR on IFN-γ+TNF-α+IL-2+ cells (%) | 51 | 0.946 (0.888–1.000) | 95.00% (76.39–99.11%) | 82.14% (64.41–92.12%) | 79.17% (59.53–90.76%) | 95.83% (79.76–99.26%) | 5.32 (2.39–11.85) | 0.06 (0.01–0.41) | 87.50% |
MTB, Mycobacterium tuberculosis; ATB, active tuberculosis; LTBI, latent tuberculosis infection; AUC, area under the curve; PPV, positive predictive value; NPV, negative predictive value; PLR, positive likelihood ratio; NLR, negative likelihood ratio; CI, confidence interval.