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. 2021 Aug 26;12:735014. doi: 10.3389/fimmu.2021.735014

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Copyright © 2021 Jiao, An, Tran, Du, Wang, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AS1517499 inhibits STAT6 activation in the kidney with obstructive injury. (A) Representative photomicrographs of kidney sections at day 10 of UUO stained for phosphorylated STAT6 (brown) and counterstained with hematoxylin (blue). Scale bar, 50μm. (B) Quantitative analysis of phosphorylated STAT6-positive cells in the kidney. ***P < 0.001 vs. Vehicle-CON; ^## P < 0.01 vs Vehicle-UUO; ⁺⁺ P < 0.01 vs AS-UUO. n = 6 per group. (C) Representative Western blots show protein levels of p-STAT6 and STAT6 in the kidney at day 10 of UUO. (D) Quantitative analysis p-STAT6 protein levels in the kidney. ***P < 0.001 vs. Vehicle-CON; ^# P < 0.05 vs Vehicle-UUO; ⁺ P < 0.05 vs AS-UUO. n = 6 per group.