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. 2021 Aug 26;12:735014. doi: 10.3389/fimmu.2021.735014

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Copyright © 2021 Jiao, An, Tran, Du, Wang, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AS1517499 reduces myofibroblast formation in folic acid nephropathy. (A) Representative photomicrographs of kidney sections 2 weeks after vehicle or AS1517499 treatment stained for α-SMA (green) and counterstained with DAPI (blue). Scale bar, 50μm. (B) Quantitative analysis of α-SMA positive area in the kidney. ***P < 0.001 vs CON; ^### P < 0.001 vs FA+Veh. n = 6 per group. (C) Representative Western blots showing α-SMA protein levels in the kidney 2 weeks after vehicle or AS1517499 treatment. (D) Quantitative analysis of α-SMA protein expression in the kidney. ***P < 0.001 vs CON, ^## P < 0.01 vs FA+Veh. n = 6 per group.