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. 2021 Aug 26;12:735014. doi: 10.3389/fimmu.2021.735014

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Copyright © 2021 Jiao, An, Tran, Du, Wang, Zhou and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AS1517499 reduces kidney fibrosis and preserve kidney function in folic acid nephropathy. (A) Representative photomicrographs of kidney sections 2 weeks after vehicle or AS1517499 treatment stained with sirius red for evaluation of total collagen deposition in the kidney. Scale bar, 50μm. (B) Quantitative analysis of interstitial collagen deposition in the kidney. ***P < 0.001 vs CON, ^## P < 0.01 vs FA+Veh. n = 6 per group. (C) Representative photomicrographs of kidney sections stained for fibronectin (green) and counterstained with DAPI (blue). Scale bar, 50μm. (D) Quantitative analysis of fibronectin-positive area in FA treated kidneys. ***P < 0.001 vs CON, ^## P < 0.01 vs FA+Veh. n = 6 per group. (E) Representative photomicrographs of kidney sections stained for collagen I (green) and counterstained with DAPI (blue). Scale bar, 50μm. (F) Quantitative analysis of collagen I positive area in the kidney. ***P < 0.001 vs CON, ^# P < 0.05 vs FA+Veh. n = 6 per group. (G) Representative Western blots showing protein expression of fibronectin and collagen I in the kidney. (H) Quantitative analysis of protein levels of fibronectin and collagen I in the kidney. ***P < 0.001 vs CON; ^## P < 0.01 vs FA+Veh. n = 6 per group. (I) Effect of AS1517499 on serum creatinine. **P < 0.001 vs CON; ^# P < 0.05 vs FA+Veh. n = 6 per group.