Table 1.
Identification of genes encoding peptides with antimicrobial activity in LCs in transcriptome studies.
| Genes | Multiple transcriptomes | Identified in the literature in non-transcriptome studies | References | Total instances identified | ||
|---|---|---|---|---|---|---|
| Number of transcriptome studies | Number of transcriptome comparisons | Comparisons | ||||
| CCL22 | 6 | 7 | LCs vs pDCs (T2, T8), LCs vs CD11c+ dermal DCs (T4), LCs vs dermal MФ (T5), LCs vs CD14+ dermal DCs (T6), LCs vs CD14+ CD1c-monocyte-derived MФ (T9) and LCs vs monocyte-derived CD14+CD1c+DCs (T9) | 1 | [Ross et al. (51)] | 8 |
| CXCL14 | 3 | 6 | LCs vs CD1c+ mDCs (T1 and T2), LCs vs pDCS (T2), LCs vs Dermal langerin- cDC2 (T9), LCs vs CD14+ CD1c-monocytederived MФ (T9) and LCs vs monocyte- derived CD14+CD1c+DCs (T9) | 0 | N/A | 6 |
| ADM | 3 | 4 | LCs vs CD1c+ mDCs (T2), LCs vs pDCS (T2), LCs 2h vs 0h (T4, T7) | 0 | N/A | 4 |
| CCL20 | 2 | 4 | LCs vs moDCs (T1), LCs vs blood CD1c+ mDCs (T1), LCs at 2h vs 0h (T7), LCs 24h vs 0h (T7) | 0 | N/A | 4 |
| B2M | 2 | 3 | LCs vs CD1c+ mDCs (T2), LCs vs CD141+ dermal DCs (T6), LCs vs CD14+ dermal DCs (T6) | 0 | N/A | 3 |
| CCL17 | 1 | 2 | LCs 24h vs 0h (T4), LCs 8h vs 0h (T4) | 1 | [Alferink et al. (52)] | 3 |
| CCL19 | 2 | 3 | LCs 8h vs 0h (T4), LCs 24h vs 0h (T4, T7) | 0 | N/A | 3 |
| CXCL2 | 2 | 2 | LCs vs blood CD1c+ mDCs (T1), LCs 2h vs 0h (T7) | 1 | [Heufler et al. (53)] | 3 |
| CCL1 | 1 | 1 | LCs 24h vs 0h (T4) | 1 | [Schaerli et al. (54)] | 2 |
| CCL2 | 2 | 2 | LCs 24h vs 0h (T4 and T7) | 0 | N/A | 2 |
| CCL27 | 1 | 2 | LCs vs moDCs (T1), LCs vs blood CD1c+ mDCs (T1), LCs 24h vs 0h, LCs 8h vs 0h (T4) | 0 | N/A | 2 |
| DEFB1 | 1 | 2 | LCs vs moDCs (T1), LCs vs blood CD1c+ mDCs (T1) | 0 | N/A | 2 |
| FURIN | 1 | 2 | LCs vs pDCs (T8), LCs vs MФ (T8) | 0 | N/A | 2 |
| GAPDH | 2 | 2 | LCs vs pDCs (T2 and T8) | 0 | N/A | 2 |
| HMGN2 | 1 | 2 | LCs vs CD141+ Dermal DCs (T6), LCs vs CD141-CD14- DCs (T6) | 0 | N/A | 2 |
| LEAP2 | 1 | 2 | LCs vs Dermal CD14+ CD1c+ DCs (T9), LCs vs Dermal Langerin+ cDC2 (T9) | 0 | N/A | 2 |
| S1007A | 1 | 2 | LCs vs moDCs (T1), LCs vs blood CD1c+ mDCs (T1) | 0 | N/A | 2 |
| SNCA | 1 | 2 | LCs vs moDCs (T1), LCs vs blood CD1c+ mDCs (T1) | 0 | N/A | 2 |
By mining publicly available data in GEO DataSets, we were able to identify 23 genes encoding antimicrobial peptides that are more strongly expressed in LCs vs. other DC subtypes and/or in LCs activated with cytokines vs. LCs with no activation. N/A, Not applicable.