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. 2021 Sep 8;8:75. doi: 10.1186/s40634-021-00391-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A Median (range) of Stance score in each group at day 0 before the first injection (D0), day 7 (D7), day 14 before the second injection (D14), 3 h after the second injection (D14 + 3), day 15 (D15), and day 22 (D22). B Mean (SEM) of ipsilateral paw withdrawal threshold in each group at D0, D7, D14, D14 + 3, D15, and D22. OA flare (filled circle, n = 31), OA (open circle, n = 30), MC non-OA (triangle, n = 12), and PBS non-OA (square, n = 9), respectively. *: P < 0.05 compared with PBS non-OA; †: P < 0.05 compared with OA