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. 2021 Sep 8;11:17822. doi: 10.1038/s41598-021-97365-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Kaplan–Meier curves and Log-Rank test for OS according to the number of metastasis. (a) Only one site metastasis. (b) Two sites metastases. 1, Bone and brain metastases; 2, Bone and liver metastases; 3, Bone and lung metastases; 4, Brain and liver metastases; 5, Brain and lung metastases; 6, Liver and lung metastases. (c) Three sites metastases. 1, Bone and brain and liver metastases; 2, Bone and brain and lung metastases; 3 Bone and liver and lung metastases; 4, Brain and liver and lung metastases; HR hazard ratio).