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. 2021 Sep 8;4:1049. doi: 10.1038/s42003-021-02562-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a UMAP of cell classes (Left) and sample groups (Right) of the integrated data from background, tumor and PDX. Endo endothelial cell, Stellate hepatic stellate cell, Eryth erythrocyte, T/NK 774 T cell or NK cell, Cho cholangiocyte, Prolif Hep proliferative hepatocyte. b Marker genes for common cell populations in liver and tumor were drawn on UMAP. DLK1 shows tumor, HPGD identifies hepatocytes, FLT1 indicates epithelial cells, COL6A3 represents hepatic stellate cells, CD163 marks Kupffer cells, and PTPRC indicates immune cells. c The heatmap for 200 most upregulated genes for cell types within background liver, tumor, and PDX (Methods). Known markers were shown on the left. Cell counts are shown in bar charts.