Table 1.

HB Patient Clinical Information. Staging, histology, diagnostic, and outcome data for HB patients evaluated in this study (follow-up is time from sample collection).

Patient #	Sample source	PRETEXT stage	Histology	Invasion on path	Metastasis	Patient qutcomes	Follow-up (Days)	PDX model
17	Liver	N/A	HB—epithelial (fetal, embryonal), macrotrabecular, poorly differentiated small cell with anaplastic features	Negative margins, vascular invasion	None	Deceased	139	X
18	Liver	N/A	HB—epithelial (fetal & embryonal), mesenchymal without teratoid features, HCC-like; 50% viable	Negative margins, lymphovascular invasion	None	Alive without disease	970	X
20	Liver	IV	HCC—Grade 3-4	Positive margin, vascular invasion, negative LN (0/1)	None	Deceased	171
21	Liver	IV—P,E,F	HB—epithelial (embryonal), pleomorphic, HCC like; 80% viable	Focal positive margins, lymphovascular invasion, negative LN (0/3)	None	Alive without disease	946	X
22	Liver	III—F,C	HB—small foci of treated disease, no subtypes specified	Focal positive margin, LN negative (0/1)	None	Alive without disease	773
23	Liver	III—P,V,C	HB—Mild pleomorphism, otherwise treated disease; 25% viable	Negative margins	None	Alive without disease	835	X
24	Liver	IV—V,P,E,F,C,M	HB—HCC-like, small cell undifferentiated, mesenchymal osteoid; 5–15% viable	Negative margins, focal tumor rupture, vascular invasion, LN negative (0/1)	Bilateral lungs	Alive with lung recurrence	742
25	Liver	IV—V,P,F,M	HB—epithelial (fetal), osteoid; <10% viable	Focally positive margins with nonviable tumor, vascular invasion, LN negative (0/3)	Bilateral lungs	Alive without disease	805
26	Liver	IV—F,C	HB—epithelial (embryonal, fetal), blastemal component; 15% viable	Negative margins, lymphovascular invasion, LN negative (0/1)	None	Alive without disease	790
27	Liver	III—C,M	HB—epithelial (fetal, embryonal), osteoid; 45% viable	Negative margins, lymphovascular invasion, LN negative (0/1)	Bilateral lungs	Alive without disease	742
28	Liver	III—M	HB—osteoid, epithelial (fetal), undifferentiated small cell; 15% viable	Margin positive, lymphovascular invasion, LN negative (0/2)	Bilateral lungs	Alive without disease	762
30	Liver	IV—M	HB—epithelial (fetal, embryonal), transitional, small cell undifferentiated, HCC like, pleomorphic; 80% viable	Negative margins, lymphovascular invasion	Bilateral lungs	Alive with liver recurrence	670	X
31	Liver	II—M	HB—epithelial (fetal, embryonal), mesenchymal, with blastema; 50% viable	Margin positive, lymphovascular invasion, LN negative (0/2)	Bilateral lungs	Alive with metastatic disease	664
38	Liver	IV—P,V,F,C	HB—epithelial, mesenchymal with teratoid features. 50% viable	Negative margins, vascular invasion, LN negative (0/6)	None	Alive without disease	557
53	Liver	IV—P,V	HB—epithelial (embryonal, pleomorphic) and HCC-like; focal mesenchymal with osteoid. 50% viable	Negative margins, vascular invasion, LN negative (0/5)	Bilateral lungs	Alive without disease	269