Table 3.

Results of the meta-analysis for continuous and dichotomous response outcome in additive model.

HLA protein, position, amino-acid(s) or HLA allele	Meta-analysis continous scale			Meta-analysis dichotomous scale			AF GWAS1 (%)			AF GWAS2 (%)
	Beta	P-value	Q	OR	P-value	Q	All (N = 772)	Non-responder (N = 186)	Responder (N = 418)	All (N = 1080)	Non-responder (N = 201)	Responder (N = 685)
HLA-DRB1, 74, alanine and leucine	0.32	1.94 × 10−3	0.27	1.32	2.22 × 10−3	0.27	70.27	65.24	72.37	71.19	67.41	73.07
HLA-DRB1, 74, arginine and glutamic acid	− 0.37	3.54 × 10−3	0.27	0.72	2.87 × 10−3	0.27	16.13	19.52	13.52	16.31	19.40	15.47
HLA-DQB1*02	− 0.33	3.96 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 74, alanine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 71, lysine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 55, leucine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 52, leucine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 47, phenylalanine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 46, glutamic acid	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 37, isoleucine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 30, serine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, 28, serine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61
HLA-DQB1, -10, serine	− 0.33	3.87 × 10−3	0.27	0.75	5.40 × 10−3	0.27	21.70	26.20	20.33	20.57	22.89	18.61

AF: allele frequency; Q-value: the q-value gives the expected positive false discovery rate; Non-resp = Li non responders (ALDA subscale A less than or equal to 3); Resp = Li responders (ALDA subscale A greater than or equal to 7).