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. 2021 Sep 8;11:17812. doi: 10.1038/s41598-021-96902-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Change in expression of selected functional categories of genes after initiation of anti-tuberculosis treatment. The graphs illustrate the percentage of genes in each functional category significantly up- (yellow) or down- (green) regulated each day relative to pretreatment expression. The left and right side graphs represent the alterations observed in gene expression with effective and ineffective treatment, respectively. The dashed line demarcates each of the functional categories. The percentage of genes was calculated by dividing the number of genes up or down-regulated by the number of genes detected. This calculation was for genes detected at each profiled time point in the functional group.