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. 2021 Sep 8;11:17812. doi: 10.1038/s41598-021-96902-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heat map of fold-change genes differentially expressed between Days 1 to 14 of treatment. The top image (A) denotes the heat map of Mtb-specific genes evaluated in patients who received effective treatment, and the bottom image (B) denotes the heat map of Mtb-specific genes evaluated in patients who received ineffective treatment. The heat maps were generated with log2 fold change values using the Clustvis web tool. No scaling was applied to rows. Imputation was used for missing value estimation. Rows were clustered using Euclidean distance and average linkage.