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. 2021 Sep 8;12(9):839. doi: 10.1038/s41419-021-04128-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Gene expression profile of CISD3 in various kinds of TCGA cancers and its homologous normal samples, which is obtained from the GEPIA website (http://gepia.cancer-pku.cn/index.html). B CISD3 expression was classified into two subgroups (high or low group) using the median level of CISD3 expression as the cut-off value. Survival map of Hazards Ratio (HR) for overall survival (OS) and disease-free survival (DFS) according to the low and high expression levels of CISD3 mRNA. C The proliferation of HT-1080 cells with different CISD3 expressions was detected by the EdU incorporation assay. Nuclei were visualized with Hoechst 33342. Scale bar: 50 μm. D Mitochondrial iron levels measured by RPA staining in control, shCISD3, and CISD3res HT-1080 cells and images were captured by confocal microscopy. Scale bar: 5 μm.