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. 2021 Sep 8;12(9):839. doi: 10.1038/s41419-021-04128-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A The growth curves representing the average size of xenografts in mice harboring HT1080 cells with altered CISD3 expression in the presence or absence of erastin administration. Tumor volume was monitored every two days and calculated using the formula: 0.5 × a × b². B The body weight curves of mice in indicated groups. NS indicates no statistical significance. C The morphological images of dissected xenografts in indicated groups. D Xenografts in each group were lysed and the ATP content was analyzed. E H&E staining and IHC analysis for CISD3, Ki-67, 4HNE, and MDA in indicated tumor tissues. Representative images were showed and the statistical columns were quantified via relative integrated optical density (IOD) value and showed on the right. *P < 0.05, **P < 0.01 between indicated groups.