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. 2021 Aug 26;12:726182. doi: 10.3389/fendo.2021.726182

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Copyright © 2021 Phimphilai, Pothacharoen and Kongtawelert

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of AGER, BAX and BCL2 genes. Comparison of the expression of the AGER, and BAX/BCL2 ratio between PBMC-isolated from subjects with diabetes with preserved osteogenic differentiation potential (DM-pD) and PBMC-isolated from diabetics with impaired osteogenic differentiation potential (DM-iD) by using age- and pentosidine-matched PBMC-isolated from non-diabetics with preserved osteogenic differentiation (NDM-pD) as a reference group. DM-iD showed higher expression of AGER and BAX/BCL2 ratio than the reference by 6.6 and 5.0 times, respectively, while DM-pD showed similar expression of AGER and BAX/BCL2 ratio to the reference. The expression of AGER and BAX/BCL2 ratio in DM-iD was significantly higher than that in DM-pD.